Terry Powley

Terry Powley

Address:
Terry T. Powley, Ph.D.
Distinguished Professor
School of Health and Human Sciences
703 3rd Street
West Lafayette, IN
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Homepage

The Powley laboratory team has taken a leadership role in developing and refining the newest neuroscience and neuroanatomical protocols for characterizing the autonomic innervation of the GI tract. Much of their work has focused directly on the circuitry of the stomach.

The team has published a number of papers on adaptations of tracer techniques, immunohistochemistry, and microscopy, and it has used those methods to advance the understanding of the neural circuits which control the upper GI tract and provide brain-gut coordination. One illustration of the Powley laboratory’s contribution is the present understanding of vagal afferent receptors in the gut wall. When the team began its analyses of the extrinsic projections to the gut, only one type of vagal sensory ending in the GI tract wall was defined structurally and characterized morphologically; five have now been described. Of these five, the Powley team is responsible for isolating, characterizing, naming and mapping four of the five receptor types. Another example of the team’s progress, one focused on efferent innervation, is its recent characterization of the vagal motor units that execute the programs of esophageal peristalsis that are generated in the brainstem and projected directly to the muscle sheets of the esophagus.

Research agenda

Two series of experiments will close critical gaps in the current characterization of the autonomic connectome controlling stomach function, thus providing the needed foundation for next generation neuromodulation protocols that can correct shortcomings in past, first-generation open-loop bioelectronic attempts to ameliorate and monitor gastric disorders. Building on recent advances in mapping of vagal circuits, many reported by the research team, the investigators will complete inventories of the efferent and afferent terminal phenotypes, analyze their collateral connections and specializations, establish their regional distributions, and identify chemical taxonomies of their target tissues. To facilitate translational extrapolations, the team will also compare the neural circuitry of the human (and pig, an ideal large animal preclinical proof-of-principle model) stomach with that of the rat model. The analyses will use a suite of high-definition neural tracing, immunohistochemical and molecular protocols, along with advanced imaging and morphometric techniques, and the research team will concentrate on those elements of gastric neural network that may be most relevant for identifying localized sites in the stomach wall where neuromodulation with state-of-the-art stimulator technologies will have strong therapeutic potential.

Selected publications

  • Wang F.B., Powley T.L. (2000). Topographic inventories of vagal afferents in gastrointestinal muscle. The Journal of Comparative Neurology. 421(3), 302-24. PMID: 10813789.
  • Powley T.L., Spaulding R.A., Haglof S.A. (2011). Vagal afferent innervation of the proximal gastrointestinal tract mucosa: chemoreceptor and mechanoreceptor architecture. The Journal of Comparative Neurology. 519(4), PMID: 21246548.
  • Powley T.L., Mittal R.K., Baronowsky E.A., Hudson C.N., Martin F.N., et al. (2013) Architecture of vagal motor units controlling striated muscle of esophagus: peripheral elements patterning peristalsis? Autonomic Neuroscience: Basic & Clinical. 179(1-2), 90-8. PMID: 24044976.
  • Powley, T.L., Hudson, C.N., McAdams, J.L., Baronowsky, E.A., Martin, F.N., Mason, J.K., & Phillips, R.J. (2014). Organization of vagal afferents in pylorus: mechanoreceptors arrayed for high sensitivity and fine spatial resolution? Autonomic Neuroscience 183, 36-48. PMCID: PMC4058399.
  • Powley, T.L., Hudson, C.N., McAdams, J.L., Baronowsky, E.A., & Phillips, R.J. (2015). Vagal Intramuscular Arrays: The specialized mechanoreceptor arbors that innervate the smooth muscle layers of the stomach examined in the rat. Journal of Comparative Neurology [Epub ahead of print]. PMID: 26355387.

Debug Console

Close6 MBRequestSessionTimelineDatabase29Events23
$_GET
Array( ) Array(

)
$_POST
Array( ) Array(

)
$_COOKIE
Array( ) Array(

)
$_SERVER
Array( REDIRECT_SCRIPT_URL => /sci/terry-powley, REDIRECT_SCRIPT_URI => https://sparc.purdue.... Array(
REDIRECT_SCRIPT_URL => /sci/terry-powley,
REDIRECT_SCRIPT_URI => https://sparc.purdue.edu/sci/terry-powley,
REDIRECT_nokeepalive => ,
REDIRECT_HTTPS => on,
REDIRECT_SSL_TLS_SNI => sparc.purdue.edu,
REDIRECT_STATUS => 200,
SCRIPT_URL => /sci/terry-powley,
SCRIPT_URI => https://sparc.purdue.edu/sci/terry-powley,
nokeepalive => ,
HTTPS => on,
SSL_TLS_SNI => sparc.purdue.edu,
HTTP_HOST => sparc.purdue.edu,
HTTP_ACCEPT_ENCODING => x-gzip, gzip, deflate,
HTTP_USER_AGENT => CCBot/2.0 (http://commoncrawl.org/faq/),
HTTP_ACCEPT => text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8,
HTTP_IF_MODIFIED_SINCE => Wed, 26 Jul 2017 16:43:41 GMT,
PATH => /sbin:/usr/sbin:/bin:/usr/bin,
SERVER_SIGNATURE => ,
SERVER_SOFTWARE => Apache/2.2.15 (CentOS),
SERVER_NAME => sparc.purdue.edu,
SERVER_ADDR => 192.168.1.57,
SERVER_PORT => 443,
REMOTE_ADDR => 54.156.93.60,
DOCUMENT_ROOT => /var/www/kermit,
SERVER_ADMIN => root@localhost,
SCRIPT_FILENAME => /var/www/kermit/index.php,
REMOTE_PORT => 48034,
REDIRECT_URL => /sci/terry-powley,
GATEWAY_INTERFACE => CGI/1.1,
SERVER_PROTOCOL => HTTP/1.0,
REQUEST_METHOD => GET,
QUERY_STRING => ,
REQUEST_URI => /sci/terry-powley,
SCRIPT_NAME => /index.php,
PHP_SELF => /index.php,
REQUEST_TIME_FLOAT => 1506416338.03,
REQUEST_TIME => 1506416338
)
separator .
orderBy id
orderDir asc
1 registerIP
2 access
always
renew
tracker.sid 3fa37489886e7cbe345b3c7a286b4a7c
tracker.ssid 3fa37489886e7cbe345b3c7a286b4a7c
tracker.rsid 3fa37489886e7cbe345b3c7a286b4a7c
  • site 0.133 seconds (+0.133); 3.50 MB (+3.500) - afterInitialise
  • site 0.236 seconds (+0.103); 4.25 MB (+0.750) - afterRoute
  • site 0.389 seconds (+0.153); 5.25 MB (+1.000) - afterDispatch
  • site 0.455 seconds (+0.065); 5.50 MB (+0.250) - beforeRenderModule mod_breadcrumbs (Breadcrumbs)
  • site 0.464 seconds (+0.010); 5.50 MB (0.000) - afterRenderModule mod_breadcrumbs (Breadcrumbs)
  • site 0.465 seconds (+0.001); 5.50 MB (0.000) - beforeRenderModule mod_menu (Main Menu)
  • site 0.618 seconds (+0.153); 5.75 MB (+0.250) - afterRenderModule mod_menu (Main Menu)
  • site 0.619 seconds (+0.001); 5.75 MB (0.000) - beforeRenderModule mod_search (Search)
  • site 0.624 seconds (+0.004); 5.75 MB (0.000) - afterRenderModule mod_search (Search)
  • site 0.629 seconds (+0.005); 5.75 MB (0.000) - onAfterRender
  • site 0.649 seconds (+0.020); 5.75 MB (0.000) - sessionStore
6 MB

29 Queries Logged: 0.0081400871276855 seconds

  1. SELECT data
      FROM `jos_session`
      WHERE `session_id` = 'acd11ca03a546ec9a97a5ce3bdd518ac'
  2. DELETE
      FROM`jos_session`
      WHERE `session_id` = 'acd11ca03a546ec9a97a5ce3bdd518ac'
  3. SELECT data
      FROM `jos_session`
      WHERE `session_id` = '3fa37489886e7cbe345b3c7a286b4a7c'
  4. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_languages'
  5. SELECT session_id
      FROM `jos_session`
      WHERE `session_id` = '3fa37489886e7cbe345b3c7a286b4a7c'
      LIMIT 1
  6. INSERT INTO `jos_session` (`session_id`,`client_id`,`time`,`ip`)
      VALUES ('3fa37489886e7cbe345b3c7a286b4a7c','0','1506416338','54.156.93.60')
  7. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_members'
  8. SELECT b.id
      FROM `jos_usergroups` AS `a`
      LEFT JOIN jos_usergroups AS b
      ON b.lft <= a.lft
      AND b.rgt >= a.rgt
      WHERE `a`.`id` = '1'
  9. SELECT *
      FROM `jos_viewlevels`
  10. SELECT folder AS type,element AS name,protected,params
      FROM `jos_extensions`
      WHERE `enabled` >= '1'
      AND `type` = 'plugin'
      AND `state` >= '0'
      AND `access` IN ('1','1','4')
      ORDER BY `ordering` ASC
  11. SELECT m.id,m.menutype,m.title,m.alias,m.note,m.path AS route,m.link,m.type,m.level,m.language,m.browserNav,m.access,m.params,m.home,m.img,m.template_style_id,m.component_id,m.parent_id,e.element AS component
      FROM `jos_menu` AS `m`
      LEFT JOIN jos_extensions AS e
      ON e.extension_id = m.component_id
      WHERE `m`.`published` = '1'
      AND `m`.`parent_id` > '0'
      AND `m`.`client_id` = '0'
      ORDER BY `m`.`lft` ASC
  12. SELECT jos_template_styles.id,jos_template_styles.home,jos_template_styles.template,jos_template_styles.params,jos_extensions.protected
      FROM `jos_template_styles`
      INNER JOIN jos_extensions
      ON jos_extensions.element = jos_template_styles.template
      WHERE `jos_template_styles`.`client_id` = '0'
      AND `jos_extensions`.`enabled` = '1'
      AND `jos_extensions`.`type` = 'template'
      AND jos_extensions.`client_id` = `jos_template_styles`.`client_id`
      AND `jos_template_styles`.`id` = '15'
      ORDER BY `home` DESC
  13. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_content'
  14. SELECT *
      FROM jos_languages
      WHERE published=1
      ORDER BY ordering ASC
  15. SELECT a.rules
      FROM `jos_assets` AS `a`
      WHERE `a`.`id` = '1'
      GROUP BY a.id, a.rules, a.lft
  16. SELECT b.rules
      FROM `jos_assets` AS `a`
      LEFT JOIN jos_assets AS b
      ON b.lft <= a.lft
      AND b.rgt >= a.rgt
      WHERE `a`.`name` = 'com_content'
      GROUP BY b.id, b.rules, b.lft
      ORDER BY `b`.`lft` ASC
  17. SELECT a.id, a.asset_id, a.title, a.alias, a.title_alias, a.introtext, a.fulltext,
      CASE WHEN badcats.id is null THEN a.state ELSE 0 END AS state, a.mask, a.catid, a.created, a.created_by, a.created_by_alias,
      CASE WHEN a.modified = 0 THEN a.created ELSE a.modified END as modified, a.modified_by, a.checked_out, a.checked_out_time, a.publish_up, a.publish_down, a.images, a.urls, a.attribs, a.version, a.parentid, a.ordering, a.metakey, a.metadesc, a.access, a.hits, a.metadata, a.featured, a.language, a.xreference,c.title AS category_title, c.alias AS category_alias, c.access AS category_access,u.name AS author,(0) as contactid,parent.title as parent_title, parent.id as parent_id, parent.path as parent_route, parent.alias as parent_alias,ROUND(v.rating_sum / v.rating_count, 0) AS rating, v.rating_count as rating_count
      FROM jos_content AS a
      LEFT JOIN jos_categories AS c
      on c.id = a.catid
      LEFT JOIN jos_users AS u
      on u.id = a.created_by
      LEFT JOIN jos_categories as parent
      ON parent.id = c.parent_id
      LEFT JOIN jos_content_rating AS v
      ON a.id = v.content_id
      LEFT
      OUTER JOIN (SELECT cat.id as id
      FROM jos_categories AS cat JOIN jos_categories AS parent
      ON cat.lft BETWEEN parent.lft
      AND parent.rgt
      WHERE parent.extension = 'com_content'
      AND parent.published <= 0
      GROUP BY cat.id) AS badcats
      ON badcats.id = c.id
      WHERE a.id = 35
      AND (a.publish_up = '0000-00-00 00:00:00' OR a.publish_up <= '2017-09-26 08:58:58')
      AND (a.publish_down = '0000-00-00 00:00:00' OR a.publish_down >= '2017-09-26 08:58:58')
      AND (a.state = 1 OR a.state =2)
  18. SELECT c.*,
      CASE WHEN CHAR_LENGTH(c.alias) THEN CONCAT_WS(':', c.id, c.alias) ELSE c.id END as slug
      FROM jos_categories as c
      LEFT JOIN jos_categories AS s
      ON (s.lft <= c.lft
      AND s.rgt >= c.rgt) OR (s.lft > c.lft
      AND s.rgt < c.rgt)
      LEFT JOIN (SELECT cat.id as id
      FROM jos_categories AS cat JOIN jos_categories AS parent
      ON cat.lft BETWEEN parent.lft
      AND parent.rgt
      WHERE parent.extension = 'com_content'
      AND parent.published != 1
      GROUP BY cat.id) AS badcats
      ON badcats.id = c.id
      WHERE (c.extension='com_content' OR c.extension='system')
      AND c.access IN (1,1,4)
      AND c.published = 1
      AND s.id=26
      AND badcats.id is null
      GROUP BY c.id, c.asset_id, c.access, c.alias, c.checked_out, c.checked_out_time, c.created_time, c.created_user_id, c.description, c.extension, c.hits, c.language, c.level, c.lft, c.metadata, c.metadesc, c.metakey, c.modified_time, c.note, c.params, c.parent_id, c.path, c.published, c.rgt, c.title, c.modified_user_id
      ORDER BY c.lft
  19. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_search'
  20. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_users'
  21. SELECT m.id,m.title,m.module,m.position,m.content,m.showtitle,m.params,mm.menuid,e.protected
      FROM `jos_modules` AS `m`
      LEFT JOIN jos_modules_menu AS mm
      ON mm.moduleid = m.id
      LEFT JOIN jos_extensions AS e
      ON e.element = m.module
      AND e.client_id = m.client_id
      WHERE `m`.`published` = '1'
      AND `e`.`enabled` = '1'
      AND (`m`.`publish_up` = '0000-00-00 00:00:00' OR `m`.`publish_up` <= '2017-09-26 08:58:58' )
      AND (`m`.`publish_down` = '0000-00-00 00:00:00' OR `m`.`publish_down` >= '2017-09-26 08:58:58' )
      AND `m`.`access` IN ('1','1','4')
      AND `m`.`client_id` = '0'
      AND (`mm`.`menuid` = '154' OR `mm`.`menuid` <= '0' )
      ORDER BY `m`.`position` ASC,`m`.`ordering` ASC
  22. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_resources'
  23. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_collections'
  24. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_blog'
  25. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_tags'
  26. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_wiki'
  27. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_groups'
  28. SELECT extension_id AS id,element AS "option",params,enabled
      FROM `jos_extensions`
      WHERE `type` = 'component'
      AND `element` = 'com_answers'
  29. UPDATE `jos_session`
      SET `data` = '__default|a:9:{s:15:\"session.counter\";i:1;s:19:\"session.timer.start\";i:1506416338;s:18:\"session.timer.last\";i:1506416338;s:17:\"session.timer.now\";i:1506416338;s:8:\"registry\";O:23:\"Hubzero\\Config\\Registry\":2:{s:7:\"\0*\0data\";O:8:\"stdClass\":1:{s:1:\"0\";s:7:\"session\";}s:9:\"separator\";s:1:\".\";}s:4:\"user\";C:17:\"Hubzero\\User\\User\":22:{a:1:{s:5:\"guest\";b:1;}}s:11:\"tracker.sid\";s:32:\"3fa37489886e7cbe345b3c7a286b4a7c\";s:12:\"tracker.ssid\";s:32:\"3fa37489886e7cbe345b3c7a286b4a7c\";s:12:\"tracker.rsid\";s:32:\"3fa37489886e7cbe345b3c7a286b4a7c\";}',`time` = '1506416338',`ip` = '54.156.93.60'
      WHERE `session_id` = '3fa37489886e7cbe345b3c7a286b4a7c'
  • onAfterInitialise Method plgSystemP3p::onAfterInitialise /core/plugins/system/p3p/p3p.php:45
  • onAfterInitialise Method plgSystemRemember::onAfterInitialise /core/plugins/system/remember/remember.php:44
  • onAfterInitialise Method plgSystemHubzero::onAfterInitialise /core/plugins/system/hubzero/hubzero.php:46
  • onAfterInitialise Method plgSystemXFeed::onAfterInitialise /core/plugins/system/xfeed/xfeed.php:46
  • onAfterInitialise Method plgSystemSupergroup::onAfterInitialise /core/plugins/system/supergroup/supergroup.php:138
  • onAfterRoute Method plgSystemJquery::onAfterRoute /core/plugins/system/jquery/jquery.php:46
  • onAfterRoute Method plgSystemSpamjail::onAfterRoute /core/plugins/system/spamjail/spamjail.php:46
  • onAfterRoute Method plgSystemIncomplete::onAfterRoute /core/plugins/system/incomplete/incomplete.php:46
  • onAfterRoute Method plgSystemUnconfirmed::onAfterRoute /core/plugins/system/unconfirmed/unconfirmed.php:46
  • onAfterRoute Method plgSystemUnapproved::onAfterRoute /core/plugins/system/unapproved/unapproved.php:46
  • onAfterRoute Method plgSystemPassword::onAfterRoute /core/plugins/system/password/password.php:46
  • onContentPrepare Method plgContentLoadmodule::onContentPrepare /core/plugins/content/loadmodule/loadmodule.php:60
  • onContentPrepare Method plgContentEmailcloak::onContentPrepare /core/plugins/content/emailcloak/emailcloak.php:49
  • onContentPrepare Method plgContentPagebreak::onContentPrepare /core/plugins/content/pagebreak/pagebreak.php:57
  • onContentPrepare Method plgContentXhubtags::onContentPrepare /core/plugins/content/xhubtags/xhubtags.php:50
  • onContentPrepare Method plgContentFormatwiki::onContentPrepare /core/plugins/content/formatwiki/formatwiki.php:85
  • onContentPrepare Method plgContentFormathtml::onContentPrepare /core/plugins/content/formathtml/formathtml.php:130
  • onContentBeforeDisplay Method plgContentPagenavigation::onContentBeforeDisplay /core/plugins/content/pagenavigation/pagenavigation.php:49
  • onContentBeforeDisplay Method plgContentVote::onContentBeforeDisplay /core/plugins/content/vote/vote.php:57
  • onAfterDispatch Method plgSystemMobile::onAfterDispatch /core/plugins/system/mobile/mobile.php:47
  • onAfterDispatch Method plgSystemDebug::onAfterDispatch /core/plugins/system/debug/debug.php:87
  • onAfterDispatch Method PlgSystemHighlight::onAfterDispatch /core/plugins/system/highlight/highlight.php:49
  • onAfterRender Method plgSystemSef::onAfterRender /core/plugins/system/sef/sef.php:45