Matthew P. WardAddress:
Matthew P. Ward, Ph.D.
Research Assistant Professor
Biomedical Engineering, MJIS 3029
206 South Martin Jischke Drive
West Lafayette, IN
tel.: (765) 494-8181
Matthew Ward is a Research Assistant Professor in the Weldon School of Biomedical Engineering at Purdue University, West Lafayette, IN. His work aims to develop and translate technologies that enable persistent, bidirectional communication with the peripheral and central nervous system. Dr. Ward holds a Ph.D. in neural engineering, with nearly a decade of training and experience in bioelectronic medicine, signal processing, pre-clinical studies, and autonomous neural control algorithm development. His technology and research into noninvasive neural interfaces are part of two ongoing clinical studies at the Indiana University School of Medicine. He has three licensed patents and is a co-founder of Drug Free Therapeutix, LLC, a pain management company developing self-optimizing, personalized pain management devices. Dr. Ward was inducted into the Purdue Innovators Hall of Fame in 2014 for his work in self-optimizing neural interfaces. DARPA, GlaxoSmithKline, Indiana CTSI, and the Indiana University School of Medicine Division of Gastroenterology and Hepatology fund his research.
To optimize and validate stimulus parameters and electrode placements for modulating stomach function in rodents, we will use the state-of-the-art circuit maps we have generated and assess response efficacy to stimulation in acute (compound action potentials; smooth muscle activity, gastric hormone levels), short-term (MRI of gastric emptying; fMRI of stimulation-elicited CNS activation patterns; micro-behavioral assays of feeding), and long-term (ingestion patterns; obesity) experiments. We will also extend an ongoing translational experiment in the clinic to examine the role of vagal afferent fibers in modulating nausea and vomiting in patients receiving gastric stimulation for diabetic gastroparesis.
- Ward, M.P., Rajdev, P., Ellison, C. & Irazoqui, P.P. (2009). Toward a comparison of microelectrodes for acute and chronic recordings. Brain Research, 1282, 183-200.
- Ward, M.P. & Irazoqui, P.P. (2010). Evolving refractory major depressive disorder diagnostic and treatment paradigms: toward closed-loop therapeutics. Frontiers in Neuroengineering, 3(7), 1-15.
- Ward, M.P., Qing, K., Otto, K.J., John, S.W.M., Worth, R.M. & Irazoqui, P.P. (2015). A flexible platform for biofeedback-driven control and personalization of electrical nerve stimulation therapy. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 23(3), 475-484.
- Qing, K., Ward, M.P. & Irazoqui, P.P. (2015). Burst-modulated waveforms optimize electrical stimuli for charge efficiency and fiber selectivity. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 23(6), 936-945.
- Ward, M.P., Nowak, T.V., Irazoqui, P.P., Wo, J.M., Arafat, M.A. & Qing, K.Y. (2015). Gastric electrical stimulation of the antrum evokes compound cervical vagal nerve action potentials in rodents. Gastroenterology, 148(4), S-507.
- Wo, J.M., Nowak, T.V., Waseem, S., & Ward, M.P. (2016). Gastric electrical stimulation for gastroparesis and chronic unexplained nausea and vomiting. Current Treatment Options in Gastroenterology: Stomach, 1-15.